Differential mechanisms of adenosine- and ATPγS-induced microvascular endothelial barrier strengthening
نویسندگان
چکیده
منابع مشابه
Edaravone mimics sphingosine-1-phosphate-induced endothelial barrier enhancement in human microvascular endothelial cells.
Edaravone is a potent scavenger of hydroxyl radicals and is quite successful in patients with acute cerebral ischemia, and several organ-protective effects have been reported. Treatment of human microvascular endothelial cells with edaravone (1.5 microM) resulted in the enhancement of transmonolayer electrical resistance coincident with cortical actin enhancement and redistribution of focal adh...
متن کاملHIF-2α regulates hypoxia-induced strengthening of the human endothelial barrier by stabilizing adherens junctions
Endothelial cells (ECs) form a tight barrier to prevent vascular leakage. Although several studies reported that vascular leakage is increased during hypoxic conditions, other studies describe a protective effect. This raises the question how hypoxia specifically regulates adherens junction integrity and thus endothelial barrier function. Here, we investigated how hypoxia and the hypoxia-mimeti...
متن کاملPKC-dependent, burn-induced adherens junction reorganization and barrier dysfunction in pulmonary microvascular endothelial cells.
Rat lung microvascular endothelial cell monolayers were exposed to donor plasma from burned rats (25% total body surface area) at 1:3 dilution for 30 min. Immunofluorescence analysis revealed that concomitant with gap formation alterations were seen in the adherens junction (AJ) proteins beta-catenin and vascular endothelial-cadherin. Both of these components were shown to exist in a smooth, un...
متن کاملDephosphorylation of Y685-VE-Cadherin Involved in Pulmonary Microvascular Endothelial Barrier Injury Induced by Angiotensin II
Angiotensin II (AngII) caused pulmonary microvascular endothelial barrier injury, which induced acute aortic dissection (AAD) combined with acute lung injury (ALI). However, the exact mechanism is unclear. We investigated the role of dephosphorylation of Y685-VE-cadherin in the AngII induced pulmonary microvascular endothelial barrier injury. Mice or pulmonary microvascular endothelial cells (P...
متن کاملANP changes microvascular endothelial barrier function in vivo
Background Atrial natriuretic peptide (ANP) regulates blood pressure and volume (for review see [1]). Its receptor, the guanylyl cyclase-A (GC-A) is expressed in vascular endothelium and mediates increases in intracellular cyclic GMP levels, but the functional relevance is controversial. Notably, mice with endothelial-restricted GC-A deletion (EC GC-A KO mice) exhibit significant hypervolemia a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cellular Physiology
سال: 2018
ISSN: 0021-9541
DOI: 10.1002/jcp.26419